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PEAQX (tetrasodium hydrate)

PEAQX (tetrasodium hydrate)

Item no.	HY-12294A-10mM
Manufacturer	MedChem Express
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.0
Formula	C17H15BrN3Na4O6P
Citations	Am J Hypertens. 2021 Apr 15;hpab047.<br/>Cells. 2023 Apr 22, 12(9), 1212.<br/>Front Neurosci. 2021; 15: 703044.<br/>J Clin Invest. 2019 Sep 3;129(9):3864-3876.<br/>Neuroscience. 2018 Nov 1;391:1-12.<br/>[1]Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.<br/>[2]Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.<br/>[3]Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175.
Smiles	BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NVP-AAM077 (tetrasodium hydrate)
Available
Product Description	PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	560.15
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	H2O : 25.5 mg/mL (ultrasonic; warming)
Target	Apoptosis; iGluR
Manufacturers Target	Apoptosis; iGluR
Isoform	NMDA Receptor
Manufacturers Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12294A-10mM-safety-datasheet.pdf