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Pitolisant (oxalate)

Pitolisant (oxalate)

Item no.	HY-12199A-10mM
Manufacturer	MedChem Express
CASRN	362665-57-4
Amount	10mM*1 mL
Quantity options	100 mg 10mM*1 mL 10mg 1 ea 50mg
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.50
Citations	[1]Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75.<br/>[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9.<br/>[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169(3):632-44.
Smiles	ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1.O=C(O)C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Tiprolisant oxalate
Available
Product Description	Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
MolecularWeight	385.88
Clinical Information	Launched
Manufacturers Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	Histamine Receptor
Manufacturers Target	Histamine Receptor
Isoform	H3 Receptor
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 10mM*1 mL

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