Item no. |
HY-12170-1mg |
Manufacturer |
MedChem Express
|
CASRN |
192329-42-3 |
Amount |
1 mg |
Quantity options |
10mM*1 mL
10 mg
1 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.27 |
Formula |
C18H21N3O5S2 |
Citations |
Sci Adv. 2023 Jan 20;9(3):eadd3867.<br/>J Neuropathol Exp Neurol. 2022 Jun 3;nlac041.<br/>[1]Sørensen MD, et al. Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity. Bioorg Med Chem. 2003 Dec 1;11(24):5461-84.<br/>[2]Blavier L, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010 Jul 15;10(2):198-208.<br/>[3]Shalinsky DR, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci. 1999 Jun 30;878:236-70.<br/>[4]Ozerdem U, et al. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy. Curr Eye Res. 2000 Jun;20(6):447-53. |
Smiles |
O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
AG3340; KB-R9896 |
Similar products |
AG3340, KB-R9896 |
Available |
|
Product Description |
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3, MMP-13 and MMP-9 with Kis of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity[1][2][3][4]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
423.51 |
Clinical Information |
Phase 3 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : 2.5 mg/mL (ultrasonic; adjust pH to 4 with 1M HCl)|H2O : 2.5 mg/mL (ultrasonic; adjust pH to 3 with HCl) |
Target |
Apoptosis; MMP |
Manufacturers Target |
Apoptosis; MMP |
Isoform |
MMP-1; MMP-13; MMP-2; MMP-3; MMP-9 |
Manufacturers Pathway |
Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.