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Prinomastat

Prinomastat

Item no.	HY-12170-10mM
Manufacturer	MedChem Express
CASRN	192329-42-3
Amount	10mM*1 mL
Quantity options	10mM*1 mL 10 mg 1 mg 5 mg
Category	Oncology Food Safety Allergenes Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Neural Development Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	99.27
Citations	Sci Adv. 2023 Jan 20;9(3):eadd3867.<br/>J Neuropathol Exp Neurol. 2022 Jun 3;nlac041.<br/>[1]Sørensen MD, et al. Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity. Bioorg Med Chem. 2003 Dec 1;11(24):5461-84.<br/>[2]Blavier L, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010 Jul 15;10(2):198-208.<br/>[3]Shalinsky DR, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci. 1999 Jun 30;878:236-70.<br/>[4]Ozerdem U, et al. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy. Curr Eye Res. 2000 Jun;20(6):447-53.
Smiles	O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AG3340; KB-R9896
Available
Product Description	Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3, MMP-13 and MMP-9 with Kis of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	423.51
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : 2.5 mg/mL (ultrasonic; adjust pH to 4 with 1M HCl)\|H2O : 2.5 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Target	Apoptosis; MMP
Manufacturers Target	Apoptosis; MMP
Isoform	MMP-1; MMP-13; MMP-2; MMP-3; MMP-9
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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