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Volasertib

Volasertib

Item no.	HY-12137-50mg
Manufacturer	MedChem Express
CASRN	755038-65-4
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.41
Formula	C34H50N8O3
Citations	[1]Xie FF, et al. Volasertib suppresses tumor growth in cervical cancer. Am J Cancer Res. 2015 Nov 15;5(12):3548-59.<br/>[2]Rudolph D, et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity.Clin Cancer Res. 2009 May 1;15(9):3094-102. Epub
Smiles	O=C(C1=CC=C(C(OC)=C1)NC2=NC=C(N(C3=O)C)C(N([C@@H]3CC)C(C)C)=N2)N[C@H]4CC[C@@H](CC4)N5CCN(CC5)CC6CC6
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BI 6727
Available
Product Description	Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis. Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	618.81
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Apoptosis; Polo-like Kinase (PLK)
Manufacturers Target	Apoptosis; Polo-like Kinase (PLK)
Isoform	PLK1; PLK2; PLK3
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-12137-50mg-safety-datasheet.pdf