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LY2109761

LY2109761

Item no.	HY-12075-10mM
Manufacturer	MedChem Express
CASRN	700874-71-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Brain Cancer Neurodegeneration Markers;Research Area Oncology By Organ Bladder Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.91
Formula	C26H27N5O2
Citations	[1]Melisi D, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther, 2008, 7(4), 829-840.<br>[2]Zhang M, et al. Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res, 2011, 71(23), 7155-7167.<br>[3]Fransvea E, et al. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology, 2008, 47(5), 1557-1566.
Smiles	N12N=C(C(C3=C4C=CC(OCCN5CCOCC5)=CC4=NC=C3)=C1CCC2)C6=NC=CC=C6
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	700874-71-1
Available
Product Description	LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	441.52
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Autophagy; TGF-β Receptor
Pathway	Autophagy; TGF-beta/Smad

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-12075-10mM-safety-datasheet.pdf