R406

Item no.	HY-12067-10mM
Manufacturer	MedChem Express
CASRN	841290-81-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Lymphatic System Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.72
Formula	C28H29FN6O8S
Citations	ACS Infect Dis. 2021 Mar 12;7(3):661-671.<br>Ann Transl Med. 2019 Dec;7(23):758.<br>Arthritis Rheumatol. 2018 Sep;70(9):1419-1428. <br>Atherosclerosis. 2019 Oct;289:132-142.<br>bioRxiv. 2022 Dec 21, 519945.<br>bioRxiv. 2024 Apr 9.<br>Cell Commun Signal. 2024 Apr 2;22(1):210.<br>Cell Rep. 2023 Mar 20;42(3):112275.<br>Cell. 2018 Oct 4;175(2):442-457.e23.<br>Exp Hematol Oncol. 2022 Nov 8;11(1):88.<br>Front Pharmacol. 2022 May 5;13:885053.<br>iScience. 2024 Mar 25.<br>J Biol Chem. 2018 Apr 27;293(17):6410-6433.<br>J Pharmacol Sci. 2017 May;134(1):29-36.<br>Nat Commun. 2022 Apr 19;13(1):2136.<br>Nihon University. School of Medicine. 2014 Mar.<br>Redox Biol. 3 September 2022, 102461.<br>Scand J Immunol. 2024 Apr 26:e13371.<br>Theranostics. 2021 May 24;11(15):7308-7321.<br>Adv Mater. 2024 Mar 15:e2311283.<br>Harvard Medical School LINCS LIBRARY<br>iScience. 2024 Jan 8.<br>Mater Today Bio. 2024 Mar 22, 101037.<br>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br>SSRN. 2023 Jun 29.<br>[1]Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.<br>[2]Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.
Smiles	COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC.OS(C5=CC=CC=C5)(=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	841290-81-1
Available
Product Description	R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation[1]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	628.63
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : ≥ 61 mg/mL\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Apoptosis; FLT3; Syk
Pathway	Apoptosis; Protein Tyrosine Kinase/RTK

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