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Rigosertib

Rigosertib

Item no.	HY-12037A-5mg
Manufacturer	MedChem Express
CASRN	592542-59-1
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	98.35
Formula	C21H25NO8S
Citations	Harvard Medical School LINCS LIBRARY<br/>Int J Biol Sci. 2020 Jun 27;16(13):2382-2391.<br/>Oncol Res. 2021 Feb 11.<br/>Sci Rep. 2017 Aug 17;7(1):8629. <br/>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br/>Harvard Medical School LINCS LIBRARY<br/>[1]Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.<br/>[2]Hyoda T, et al. Rigosertib induces cell death of a myelodysplastic syndrome-derived cell line by DNA damage-induced G2/M arrest. Cancer Sci. 2015 Mar;106(3):287-93.<br/>[3]Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86.<br/>[4]Reddy MV, et al. Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem. 2011 Sep 22;54(18):6254-76.<br/>[5]Chapman CM, et al. ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91
Smiles	COC1=CC=C(C=C1NCC(O)=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ON-01910
Available
Product Description	Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	451.49
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : 75 mg/mL (ultrasonic)
Target	Apoptosis; PI3K; Polo-like Kinase (PLK)
Manufacturers Target	Apoptosis; PI3K; Polo-like Kinase (PLK)
Isoform	PLK1; PLK2
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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HY-12037A-5mg-safety-datasheet.pdf