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PD153035 (Hydrochloride)

PD153035 (Hydrochloride)

Item no.	HY-12013-50mg
Manufacturer	MedChem Express
CASRN	183322-45-4
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.78
Formula	C16H15BrClN3O2
Citations	bioRxiv. 2024 Apr 4.<br/>Biochim Biophys Acta Mol Basis Dis. 2023 Dec 13:166981.<br/>Cell Death Dis. 2022 Jul 25;13(7):647.<br/>Elife. 2015 Feb 10;4:e05178.<br/>Gen Comp Endocrinol. 2020 Dec 1;299:113616.<br/>Int J Stem Cells. 2022 Jun 30.<br/>J Toxicol Sci. 2023 Nov 14;48(12):655-663.<br/>Nat Commun. 2018 Jun 5;9(1):2174.<br/>[1]Bridges AJ, et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76.<br/>[2]Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265(5175):1093-5.<br/>[3]Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106.<br/>[4]Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302.
Smiles	COC1=C(C=C(C2=C1)N=CN=C2NC3=CC(Br)=CC=C3)OC.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SU-5271 (Hydrochloride); AG1517 (Hydrochloride); ZM 252868 (Hydrochloride)
Available
Product Description	PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	396.67
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 5.125 mg/mL (ultrasonic; warming)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	EGFR
Manufacturers Target	EGFR
Isoform	EGFR/ErbB1/HER1
Manufacturers Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-12013-50mg-safety-datasheet.pdf