DC1SMe

Item no.	HY-112898-50mg
Manufacturer	MedChem Express
CASRN	501666-85-9
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Smiles	O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	501666-85-9
Available
Product Description	DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
StorageTemperature	-20°C (Powder, stored under nitrogen, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	684.23
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	ADC Cytotoxin
Manufacturers Target	ADC Cytotoxin
Isoform	Duocarmycins
Manufacturers Pathway	Antibody-drug Conjugate/ADC Related
Manufacturers Product type	ADC Related

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HY-112898-50mg-safety-datasheet.pdf