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Ripretinib

Ripretinib

Item no.	HY-112306-10mg
Manufacturer	MedChem Express
CASRN	1442472-39-0
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Food Safety Histamines Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.33
Formula	C24H21BrFN5O2
Citations	[1]KIT/PDGFR Inhibitor DCC-2618.<br/>[2]BLU-285, DCC-2618 Show Activity against GIST. Cancer Discov. 2017 Feb;7(2):121-122.<br/>[3]Schneeweiss M, et al. The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis. Haematologica. 2018 May;103(5):799-809.
Smiles	O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	DCC-2618
Available
Product Description	Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2)[1][2]. DCC-2618 exerts antineoplastic effect and induces apoptosis[3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	510.36
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic)
Target	Apoptosis; c-Kit; FLT3; PDGFR; VEGFR
Manufacturers Target	Apoptosis; c-Kit; FLT3; PDGFR; VEGFR
Isoform	PDGFRα
Manufacturers Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-112306-10mg-safety-datasheet.pdf