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GDC-0575 (dihydrochloride)

GDC-0575 (dihydrochloride)

Item no.	HY-112167A-10mM
Manufacturer	MedChem Express
CASRN	1657014-42-0
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.49
Formula	C16H22BrCl2N5O
Citations	bioRxiv. 2023 Feb 7.<br/>Mol Cancer Res. 2020 Jan;18(1):91-104.<br/>Mol Cancer. 2024 Apr 29;23(1):86.<br/>Nat Commun. 2020 Jan 8;11(1):123. <br/>Neurotherapeutics. 2022 Mar;19(2):570-591.<br/>[1]Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8(1):1679.<br/>[2]Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Jun 15;24(12):2901-2912.
Smiles	O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ARRY-575 (dihydrochloride); RG7741 (dihydrochloride)
Available
Product Description	GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	451.19
Clinical Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 65 mg/mL (ultrasonic)\|H2O : 25 mg/mL (ultrasonic)
Target	Checkpoint Kinase (Chk)
Manufacturers Target	Checkpoint Kinase (Chk)
Isoform	Chk1
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-112167A-10mM-safety-datasheet.pdf