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PROTAC ERα Degrader-5

PROTAC ERα Degrader-5

Item no.	HY-112100-10mM
Manufacturer	MedChem Express
CASRN	2158322-33-7
Amount	10mM*1 mL
Quantity options	10mM*1 mL 10 mg 1 ea 1 mg 50mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.96
Citations	[1]Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.
Smiles	CN(C(COCCOCCNC(C1=CC=C(C(N2[C@@H](C)[C@H](NC([C@H](C)NC)=O)C(N(CC3=C(OC)C=CC4=C3C=CC=C4)C5=C2C=C(C#N)C=C5)=O)=O)C=C1)=O)=O)CCOC(C=C6)=CC=C6/C(C7=CC=C(OCC(C=C8)=CC=C8NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)C=C7)=C(C%10=CC=CC=C%10)/CC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2158322-33-7
Available
Product Description	PROTAC ERα Degrader-5 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. PROTAC ERα Degrader-5 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab)[1].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1674.93
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 70 mg/mL (ultrasonic)
Target	Estrogen Receptor/ERR; PROTAC-Linker Conjugates for PAC
Manufacturers Target	Estrogen Receptor/ERR; PROTAC-Linker Conjugates for PAC
Manufacturers Pathway	Antibody-drug Conjugate/ADC Related; PROTAC; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	ADC Related

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mM*1 mL

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