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GSK3145095

GSK3145095

Item no.	HY-111946-10mM
Manufacturer	MedChem Express
CASRN	1622849-43-7
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.39
Formula	C20H17F2N5O2
Citations	[1]Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862.
Smiles	FC1=CC(F)=CC2=C1NC([C@@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1622849-43-7
Available
Product Description	GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	397.38
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	RIP kinase
Manufacturers Target	RIP kinase
Manufacturers Pathway	Apoptosis
Manufacturers Product type	Reference compound

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HY-111946-10mM-safety-datasheet.pdf