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PROTAC RAR Degrader-1

PROTAC RAR Degrader-1

Item no.	HY-111844-5mg
Manufacturer	MedChem Express
CASRN	1351169-27-1
Amount	5 mg
Quantity options	10mg 1 mg 5 mg
Category	Oncology By Cell Type Hematology Leukemia Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	97.91
Citations	[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
Smiles	O=C(O)C1=CC=C(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)C=C1OCCCNC(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)=O)=O
ECLASS 5.1	30220300
ECLASS 6.1	30220300
ECLASS 8.0	32160605
ECLASS 9.0	32160605
ECLASS 10.0.1	32160490
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1351169-27-1
Available
Product Description	PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	917.14
Clinical_Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 80 mg/mL
Manufacturers Target	PROTACs; RAR/RXR; SNIPERs
Isoform	cIAP1
Pathway	Metabolic Enzyme/Protease; PROTAC; Vitamin D Related/Nuclear Receptor

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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