Y06036

Item no.	HY-111502-10mM
Manufacturer	MedChem Express
CASRN	1832671-96-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.96
Formula	C16H15BrN2O5S
Citations	[1]Zhang M, et al. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). J Med Chem. 2018 Apr 12;61(7):3037-3058.
Smiles	BrC1=CC(S(=O)(NC2=C(OC)C=C(ON=C3C)C3=C2)=O)=C(OC)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1832671-96-1
Available
Product Description	Y06036 is a potent and selective BET inhibitor, which binds to the BRD4(1) bromodomain with Kd value of 82 nM[1]. Antitumor activity[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	427.27
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 130 mg/mL (ultrasonic)
Target	Epigenetic Reader Domain
Manufacturers Target	Epigenetic Reader Domain
Isoform	BRD4
Manufacturers Pathway	Epigenetics
Manufacturers Product type	Reference compound

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