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Crisaborole

Crisaborole

Item no.	HY-10978-10mM
Manufacturer	MedChem Express
CASRN	906673-24-3
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 250 mg 50 mg 5 mg
Category	Food Safety Drugs Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.92
Formula	C14H10BNO3
Citations	[1]Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32. [2]Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.
Smiles	N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AN-2728, PF-06930164
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Phosphodiesterase (PDE)
Shipping Temperature	Room Temperature
Storage Conditions	Store at room temperature, keep dry and cool
Molecular Weight	251.05
Product Description	Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : ≥ 100 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	PDE4
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10978-10mM-safety-datasheet.pdf