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RO1138452

RO1138452

Item no.	HY-108912-10mg
Manufacturer	MedChem Express
CASRN	221529-58-4
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C19H23N3O
Citations	[1]Bley KR, et al. RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147(3):335-45.<br/>[2]Ayer LM, et al. 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. J Pharmacol Exp Ther. 2008 Feb;324(2):815-26.
Smiles	CC(C)OC1=CC=C(CC2=CC=C(NC3=NCCN3)C=C2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CAY10441
Available
Product Description	RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	309.41
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Endocrinology
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 50 mg/mL (ultrasonic)
Target	Prostaglandin Receptor
Manufacturers Target	Prostaglandin Receptor
Isoform	IP
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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HY-108912-10mg-safety-datasheet.pdf