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Ro 08-2750

Ro 08-2750

Item no.	HY-108466-1mg
Manufacturer	MedChem Express
CASRN	37854-59-4
Amount	1 mg
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.63
Citations	[1]Arkin MR, et al. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr;3(4):301-17.<br/>[2]Niederhauser O, et al. NGF ligand alters NGF signaling via p75(NTR) and trkA. J Neurosci Res. 2000 Aug 1;61(3):263-72.<br/>[3]Minuesa G, et al. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 2019 Jun 19;10(1):2691.
Smiles	O=CC1=C(C)C=C2N=C3C(NC(N=C3N(C)C2=C1)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	37854-59-4
Available
Product Description	Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM[3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	270.24
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Neurological Disease
Solubility	DMSO : 4 mg/mL (ultrasonic; warming; heat to 80°C)
Target	Apoptosis
Manufacturers Target	Apoptosis
Manufacturers Pathway	Apoptosis
Manufacturers Product type	Reference compound

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HY-108466-1mg-safety-datasheet.pdf