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Tropifexor

Tropifexor

Item no.	HY-107418-50mg
Manufacturer	MedChem Express
CASRN	1383816-29-2
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 200 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.35
Formula	C29H25F4N3O5S
Citations	[1]Tully DC, et al. Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). J Med Chem. 2017 Dec 8.
Smiles	FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C(C(O)=O)C=C7S6)[C@H](CC5)C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LJN452
Available
Product Description	Tropifexor (LJN452) is a highly potent agonist of FXR with an EC50 of 0.2 nM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	603.58
Clinical Information	Phase 2
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : ≥ 80.66 mg/mL
Target	Autophagy; FXR
Manufacturers Target	Autophagy; FXR
Manufacturers Pathway	Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-107418-50mg-safety-datasheet.pdf