Item no. |
HY-10627A-50mg |
Manufacturer |
MedChem Express
|
CASRN |
405911-17-3 |
Amount |
50 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Clone |
N/A |
Specific against |
other |
Purity |
99.92 |
Formula |
C33H32Cl2F3NO3 |
Citations |
bioRxiv. 2023 Mar 10.<br/>Radboud University Nijmegen. 2021 Mar.<br/>Viruses. 2022, 14(3), 514.<br/>Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. <br/>Bioconjug Chem. 2015 Nov 18;26(11):2216-22. <br/>Cancer Lett. 2023 May 5;216208.<br/>Cell Death Differ. 2020 Aug;27(8):2433-2450. <br/>J Am Heart Assoc. 2021 May 8;e018455.<br/>J Ethnopharmacol. 2023 May 24;315:116684.<br/>Sci Adv. 15 Jul 2022.<br/>Theranostics. 2020 Jul 11;10(19):8834-8850. <br/>Vet Microbiol. 2024 Jan, 288, 109948.<br/>[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.<br/>[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.<br/>[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.<br/>[4]Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6. |
Smiles |
ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
405911-17-3 |
Available |
|
Product Description |
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
618.51 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cardiovascular Disease; Cancer |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C) |
Target |
LXR |
Manufacturers Target |
LXR |
Manufacturers Pathway |
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.