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GW3965 (hydrochloride)

GW3965 (hydrochloride)

Item no.	HY-10627A-10mM
Manufacturer	MedChem Express
CASRN	405911-17-3
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.92
Formula	C33H32Cl2F3NO3
Citations	bioRxiv. 2023 Mar 10.<br/>Radboud University Nijmegen. 2021 Mar.<br/>Viruses. 2022, 14(3), 514.<br/>Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. <br/>Bioconjug Chem. 2015 Nov 18;26(11):2216-22. <br/>Cancer Lett. 2023 May 5;216208.<br/>Cell Death Differ. 2020 Aug;27(8):2433-2450. <br/>J Am Heart Assoc. 2021 May 8;e018455.<br/>J Ethnopharmacol. 2023 May 24;315:116684.<br/>Sci Adv. 15 Jul 2022.<br/>Theranostics. 2020 Jul 11;10(19):8834-8850. <br/>Vet Microbiol. 2024 Jan, 288, 109948.<br/>[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.<br/>[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.<br/>[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.<br/>[4]Collins JL, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6.
Smiles	ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	405911-17-3
Available
Product Description	GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	618.51
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	LXR
Manufacturers Target	LXR
Manufacturers Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10627A-10mM-safety-datasheet.pdf