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Gatifloxacin (hydrochloride)

Gatifloxacin (hydrochloride)

Item no.	HY-10581A-10mM
Manufacturer	MedChem Express
CASRN	121577-32-0
Amount	10mM/1mL
Quantity options	10mM/1mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.94
Formula	C19H23ClFN3O4
Citations	[1]Takei M, et al. Inhibitory activities of Gatifloxacin hydrochloride (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.Antimicrob Agents Chemother. 1998 Oct;42(10):2678-81.<br>[2]Fukuda H, et al. Antibacterial activity of Gatifloxacin hydrochloride (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother. 1998 Aug;42(8):1917-22.<br>[3]Yamada C, et al. Gatifloxacin hydrochloride acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis. Eur J Pharmacol. 2006 Dec 28;553(1-3):67-72. Epub 2006 Sep 28.<br>[4]Daw-Garza A, et al. In vivo therapeutic effect of Gatifloxacin mesylate on BALB/c mice infected with Nocardia brasiliensis.Antimicrob Agents Chemother. 2008 Apr;52(4):1549-50.
Smiles	CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AM-1155 (hydrochloride); BMS-206584 (hydrochloride); PD135432 (hydrochloride)
Similar products	AM 1155 hydrochloride, BMS 206584-01 hydrochloride, PD 135432 hydrochloride
Available
Product Description	Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	411.86
Clinical_Information	Launched
Manufacturers Research Area	Infection
Solubility	DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 10 mg/mL (ultrasonic)
Manufacturers Target	Antibiotic; Bacterial; Topoisomerase
Isoform	Quinolone; Topo II
Pathway	Anti-infection; Cell Cycle/DNA Damage

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HY-10581A-10mM-safety-datasheet.pdf