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Ketanserin (tartrate)

Ketanserin (tartrate)

Item no.	HY-10562A-10mM
Manufacturer	MedChem Express
CASRN	83846-83-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 50 mg
Category	Food Safety Drugs Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.99
Formula	C26H28FN3O9
Citations	[1]Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73. [2]Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506. [3]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76. [4]Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.
Smiles	O=C(C1=CC=CC=C1N2)N(CCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)C2=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	R41468 tartrate
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor; Autophagy; Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	545.51
Product Description	Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 25 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	5-HT2 Receptor
Clinical information	Launched

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HY-10562A-10mM-safety-datasheet.pdf