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SCH-1473759 (hydrochloride)

SCH-1473759 (hydrochloride)

Item no.	HY-10483-100mg
Manufacturer	MedChem Express
CASRN	1094067-13-6
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.79
Formula	C20H27ClN8OS
Citations	[1]Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.<br/>[2]Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.
Smiles	[H]Cl.CC1=CN2C(C(NC3=CC(CN(C(C)(CO)C)CC)=NS3)=N1)=NC=C2C4=CNN=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1094067-13-6
Available
Product Description	SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	463.00
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Aurora Kinase
Manufacturers Target	Aurora Kinase
Isoform	Aurora A; Aurora B
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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HY-10483-100mg-safety-datasheet.pdf