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Fasudil (Hydrochloride)

Fasudil (Hydrochloride)

Item no.	HY-10341-1g
Manufacturer	MedChem Express
CASRN	105628-07-7
Amount	1 g
Quantity options	10mM/1mL 1 g 200 mg 500 mg 5g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.96
Citations	Biomed Rep. 2015 May;3(3):361-364. <br>Cell Mol Immunol. 2023 Mar 2;1-14.<br>Eur J Pharmacol. 2024 May 13:975:176640.<br>Sci Rep. 2018 Feb 6;8(1):2477. <br>Transl Neurosci. 2020 Apr 20;11(1):75-86.<br>Adipocyte. 2019 Dec;8(1):114-124. <br>Br J Cancer. 2023 Mar 23.<br>Clin Transl Med. 2022 Jul;12(7):e961.<br>Clin Transl Med. 2022 Oct;12(10):e1036.<br>Inflammopharmacology. 2023 Apr 19;1-11.<br>Int J Biol Sci. 2024 Jan 12;20(3):897-915.<br>J Exp Clin Cancer Res. 2020 Jun 16;39(1):113.<br>J Pharm Pharmacol. 2021 Mar 29;rgab033.<br>Neural Regen Res. 2021 Dec;16(12):2512-2520.<br>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br>SSRN. 2023 Feb 24.<br>[1]Chen M, et al. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50.<br>[2]Huang XN, et al. The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cordbarrier following experimental autoimmune encephalomyelitis. J Neuroimmunol. 2011 Oct 28;239(1-2):61-7.<br>[3]Uehata M, et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997 Oct 30;389(6654):990-4.<br>[4]Fukushima M, et al. Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. Liver Int. 2005 Aug;25(4):829-38.<br>[5]Corbin KD, et al. Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol. 2012 Mar;28(2):159-65.<br>[6]Zhang J, et al. Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. Clin Chim Acta. 2009 Mar;401(1-2):76-80.<br>[7]Sun X, et al. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Nov;180(1-2):126-34. Epub 2006 Sep 22.
Smiles	O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HA-1077 (Hydrochloride); AT-877 (Hydrochloride)
Available
Product Description	Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca2+ channel antagonist and vasodilator[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	327.83
Clinical_Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 31 mg/mL\|H2O : 55 mg/mL (ultrasonic)
Manufacturers Target	Autophagy; Calcium Channel; HIV; PKA; PKC; ROCK
Isoform	PKA; PKC; ROCK1; ROCK2
Pathway	Anti-infection; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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