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BMS-690514

BMS-690514

Item no.	HY-10333-50mg
Manufacturer	MedChem Express
CASRN	859853-30-8
Amount	50 mg
Quantity options	10mM/1mL 10 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.07
Formula	C19H24N6O2
Citations	[1]Wong TW, et al. Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.<br/>[2]Marathe P, et al. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93.
Smiles	O[C@@H]1CN(CC[C@H]1N)CC2=C3C(NC4=CC=CC(OC)=C4)=NC=NN3C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	859853-30-8
Available
Product Description	BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	368.43
Clinical Information	Phase 2
Manufacturers Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO : ≥ 25 mg/mL
Target	EGFR; VEGFR
Manufacturers Target	EGFR; VEGFR
Isoform	EGFR/ErbB1/HER1; ErbB2/HER2; ErbB4/HER4
Manufacturers Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-10333-50mg-safety-datasheet.pdf