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PD176252

PD176252

Item no.	HY-103286-2mg
Manufacturer	MedChem Express
CASRN	204067-01-6
Amount	2mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 2mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.18
Citations	[1]Ashwood V, et al. PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94.<br/>[2]Schepetkin IA, et al. Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol Pharmacol. 2011 Jan;79(1):77-90.<br/>[3]Moody TW, et al. Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. Eur J Pharmacol. 2003 Aug 1;474(1):21-9.
Smiles	O=C(NC1=CC=C([N+]([O-])=O)C=C1)N[C@](CC2=CNC3=C2C=CC=C3)(C)C(NCC4(C5=CC=C(OC)C=N5)CCCCC4)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	204067-01-6
Available
Product Description	PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	584.67
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 115 mg/mL (ultrasonic)
Target	Bombesin Receptor
Manufacturers Target	Bombesin Receptor
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-103286-2mg-safety-datasheet.pdf