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Falnidamol

Falnidamol

Item no.	HY-10322-10mg
Manufacturer	MedChem Express
CASRN	196612-93-8
Amount	10 mg
Quantity options	10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.05
Formula	C18H19ClFN7
Citations	[1]Solca FF, et al. Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.<br/>[2]Dittrich Ch, et al. Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur J Cancer. 2002 May;38(8):1072-80.
Smiles	ClC1=CC(NC2=NC=NC3=CN=C(NC(CC4)CCN4C)N=C23)=CC=C1F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BIBX 1382
Available
Product Description	Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	387.84
Clinical Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Target	EGFR
Manufacturers Target	EGFR
Isoform	EGFR/ErbB1/HER1; ErbB2/HER2
Manufacturers Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-10322-10mg-safety-datasheet.pdf