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Cediranib

Cediranib

Item no.	HY-10205-100mg
Manufacturer	MedChem Express
CASRN	288383-20-0
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Development Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.58
Formula	C25H27FN4O3
Citations	[1]Wedge SR, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res, 2005, 65(10), 4389-4400.<br/>[2]Zhang L, et al. Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas. Sci Signal. 2015 Dec 8;8(406):ra125.
Smiles	FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AZD2171
Available
Product Description	Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	450.51
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : 20 mg/mL (ultrasonic)
Target	Autophagy; PDGFR; VEGFR
Manufacturers Target	Autophagy; PDGFR; VEGFR
Isoform	PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Manufacturers Pathway	Autophagy; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10205-100mg-safety-datasheet.pdf