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AZ PFKFB3 26

AZ PFKFB3 26

Item no.	HY-101971-10mg
Manufacturer	MedChem Express
CASRN	1704740-52-2
Amount	10 mg
Quantity options	10 mMx1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.23
Formula	C24H26N4O2
Citations	[1]Boyd S, et al. Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015 Apr 23;58(8):3611-25.
Smiles	O=C([C@H]1NCCC1)NC2=CC=C(OC3=CC4=C(N(CC(C)C)C=C4C#N)C=C3)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1704740-52-2
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	402.49
Product Description	AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 5 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Manufacturer - Pathway	Autophagy
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-101971-10mg-safety-datasheet.pdf