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Sepantronium (hydrochloride)

Sepantronium (hydrochloride)

Item no.	HY-10194A-10mg
Manufacturer	MedChem Express
CASRN	355406-09-6
Amount	10mg
Quantity options	100 mg 10mg 1 ea 50mg 5mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	95.00
Citations	[1]Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21.<br/>[2]Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.<br/>[3]Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6(25):21137-47.
Smiles	O=C(C1=C2[N+](CC3=NC=CN=C3)=C(C)N1CCOC)C4=C(C=CC=C4)C2=O.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	YM-155 (hydrochloride)
Available
Product Description	Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity[1].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	398.84
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Autophagy; Survivin
Manufacturers Target	Autophagy; Survivin
Manufacturers Pathway	Apoptosis; Autophagy
Manufacturers Product type	Reference compound

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