AU1235

Item no.	HY-101867-10mM
Manufacturer	MedChem Express
CASRN	1338780-86-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Formula	C17H19F3N2O
Citations	[1]McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14.<br/>[2]Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19.
Smiles	O=C(NC(C=CC(F)=C1F)=C1F)NC2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1338780-86-1
Available
Product Description	AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	324.34
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Infection
Solubility	DMSO : 25 mg/mL (ultrasonic)
Target	Bacterial
Manufacturers Target	Bacterial
Manufacturers Pathway	Anti-infection
Manufacturers Product type	Reference compound

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HY-101867-10mM-safety-datasheet.pdf