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GIBH-130

GIBH-130

Item no.	HY-101860-2mg
Manufacturer	MedChem Express
CASRN	1252608-59-5
Amount	2mg
Quantity options	100 mg 10mM*1 mL 10 mg 25 mg 2mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.87
Citations	[1]Zhou W, et al. Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models. ACS Chem Neurosci. 2016 Nov 16;7(11):1499-1507.
Smiles	O=C(C1=NN=C(C2=CC=CC=C2)C=C1C)N3CCN(C4=NC=CC=N4)CC3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1252608-59-5
Available
Product Description	GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the IL-1β secretion by activated microglia (IC50=3.4 nM).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	360.41
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 0.67 mg/mL (ultrasonic)
Target	Interleukin Related
Manufacturers Target	Interleukin Related
Isoform	IL-1
Manufacturers Pathway	Immunology/Inflammation
Manufacturers Product type	Reference compound

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HY-101860-2mg-safety-datasheet.pdf