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TG 100572 (Hydrochloride)

TG 100572 (Hydrochloride)

Item no.	HY-10185-10mg
Manufacturer	MedChem Express
CASRN	867331-64-4
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	98.96
Formula	C26H27Cl2N5O2
Citations	Science. 2017 Dec 1;358(6367):eaan4368.<br/>Am J Pathol. 2019 Oct;189(10):2090-2101. <br/>[1]Doukas J, et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol. 2008 Jul;216(1):29-37.<br/>[2]Palanki MS, et al. Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. J Med Chem. 2008 Mar 27;51(6):1546-59.
Smiles	ClC1=CC=C(O)C=C1C2=CC(C)=C(N=C(NC(C=C3)=CC=C3OCCN4CCCC4)N=N5)C5=C2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	867331-64-4
Available
Product Description	TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	512.43
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic)
Target	FGFR; PDGFR; Src; VEGFR
Manufacturers Target	FGFR; PDGFR; Src; VEGFR
Isoform	FGFR1; FGFR2; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1
Manufacturers Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-10185-10mg-safety-datasheet.pdf