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Tinostamustine

Tinostamustine

Item no.	HY-101780-10mM
Manufacturer	MedChem Express
CASRN	1236199-60-2
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Aging & Neurological Disorders Neural Epigenetics Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Heart & Blood Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	99.42
Formula	C19H28Cl2N4O2
Citations	[1]Mehrling T, et al. The Alkylating-HDAC Inhibition Fusion Principle: Taking Chemotherapy to the Next Level with the First in Class Molecule EDO-S101. Anticancer Agents Med Chem. 2016;16(1):20-8.
Smiles	O=C(NO)CCCCCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EDO-S101; NL-101
Available
Product Description	Tinostamustine (EDO-S101) is a pan HDAC inhibitor; inhibits HDAC6, HDAC1, HDAC2 and HDAC3 with IC50 values of 6 nM, 9 nM, 9 nM and 25 nM, respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	415.36
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	HDAC
Manufacturers Target	HDAC
Isoform	HDAC1; HDAC10; HDAC2; HDAC3; HDAC6; HDAC8
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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HY-101780-10mM-safety-datasheet.pdf