Comparison

Linrodostat European Partner

Item no. HY-101560-5mg
Manufacturer MedChem Express
CASRN 1923833-60-6
Amount 5 mg
Quantity options 100 mg 10mM/1mL 10 mg 25 mg 500 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.89
Formula C24H24ClFN2O
Citations [1]Richards T, et al. Cell based functional assays for IDO1 inhibitor screening and characterization. Oncotarget. 2018 Jul 20;9(56):30814-30820.<br/>[2]Lillian L. Siu, et al. Abstract CT116: BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.
Smiles O=C(NC1=CC=C(Cl)C=C1)[C@H](C)[C@@](CC2)([H])CC[C@H]2C3=CC=NC4=C3C=C(F)C=C4
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias BMS-986205; ONO-7701
Available
Product Description
Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor with an IC50 value of 1.1 nM in IDO1-HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers[1][2].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
Cancer-programmed cell death
MolecularWeight
410.91
Clinical Information
Phase 3
Manufacturers Research Area
Cancer
Solubility
DMSO : 50 mg/mL (ultrasonic)
Target
Indoleamine 2, 3-Dioxygenase (IDO)
Manufacturers Target
Indoleamine 2, 3-Dioxygenase (IDO)
Isoform
IDO1
Manufacturers Pathway
Metabolic Enzyme/Protease
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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