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Cyclo(his-pro)

Cyclo(his-pro)

Item no.	HY-101402-5mg
Manufacturer	MedChem Express
CASRN	53109-32-3
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 1mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.41
Formula	C11H14N4O2
Citations	[1]Grottelli S, et al. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332.<br>[2]Minelli A, et al. Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44(3):525-35.<br>[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.
Smiles	O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Cyclo(histidyl-proline); Histidylproline diketopiperazine
Available
Product Description	Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	234.25
Clinical_Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Neurological Disease
Solubility	H2O : ≥ 30 mg/mL
Manufacturers Target	Endogenous Metabolite; NF-κB
Isoform	Human Endogenous Metabolite; NF-κB
Pathway	Metabolic Enzyme/Protease; NF-κB

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HY-101402-5mg-safety-datasheet.pdf