R-IMPP

Item no.	HY-101354-10mM
Manufacturer	MedChem Express
CASRN	2133832-83-2
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Lipoprotein Receptors & Associated Proteins Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.42
Formula	C24H27N3O2
Citations	[1]Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371
Smiles	O=C(N(C1=NC=CC2=C1C=CC=C2)[C@H]3CNCCC3)CCC4=CC=C(OC)C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PF-00932239
Available
Product Description	R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	389.49
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	PCSK9
Manufacturers Target	PCSK9
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-101354-10mM-safety-datasheet.pdf