Item no. |
HY-101189-50mg |
Manufacturer |
MedChem Express
|
CASRN |
1046447-90-8 |
Amount |
50 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
1 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.71 |
Formula |
C11H19N5 |
Citations |
[1]Murata Y, et al. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.<br>[2]Savall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H4 receptor antagonists. J Med Chem. 2014 Mar 27;57(6):2429-39. |
Smiles |
NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
1046447-90-8 |
Available |
|
Product Description |
JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity[1][2]. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
221.30 |
Clinical_Information |
Phase 2 |
Manufacturers Research Area |
Neurological Disease; Endocrinology |
Solubility |
DMSO : 33.33 mg/mL (ultrasonic) |
Manufacturers Target |
Histamine Receptor |
Isoform |
H4 Receptor |
Pathway |
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.