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D-erythro-Sphingosine

D-erythro-Sphingosine

Item no.	HY-101047-25mg
Manufacturer	MedChem Express
CASRN	123-78-4
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C18H37NO2
Citations	[1]Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 ( Pt 3):699-703.<br>[2]Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172(2):683-91.<br>[3]Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30(1):22-7.<br>[4]Cheng P, et al. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359(1-2):48-56.
Smiles	CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine
Similar products	123-78-4
Available
Product Description	D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	299.49
Clinical_Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Endogenous Metabolite; Phosphatase; PKC
Isoform	Human Endogenous Metabolite; Microbial Metabolite; PKC
Pathway	Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad

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HY-101047-25mg-safety-datasheet.pdf