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10074-G5

10074-G5

Item no.	HY-100996-25mg
Manufacturer	MedChem Express
CASRN	413611-93-5
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	98.52
Formula	C18H12N4O3
Citations	[1]Clausen DM, et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335(3):715-27.<br/>[2]Chauhan J, et al. Discovery of methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem. 2014 Oct;9(10):2274-85.<br/>[3]Yap JL, et al. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23(1):370-4.
Smiles	O=[N+]([O-])C1=CC=C(NC2=CC=CC=C2C3=CC=CC=C3)C4=NON=C41
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	413611-93-5
Available
Product Description	10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	332.31
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 28 mg/mL
Target	Autophagy; c-Myc
Manufacturers Target	Autophagy; c-Myc
Manufacturers Pathway	Apoptosis; Autophagy
Manufacturers Product type	Reference compound

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HY-100996-25mg-safety-datasheet.pdf