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Navitoclax

Navitoclax

Item no.	HY-10087-10mg
Manufacturer	MedChem Express
CASRN	923564-51-6
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 25mg 500 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C47H55ClF3N5O6S3
Citations	[1]Lock R1, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50(6):1181-1189.<br/>[2]Wong M, et al. Navitoclax (ABT-263) reduces Bcl-x(L)-mediated chemoresistance in ovarian cancer models.Mol Cancer Ther. 2012 Apr;11(4):1026-1035.<br/>[3]Chen J, et al. The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther. 2011 Dec;10(12):2340-9.
Smiles	O=S(C1=CC(S(NC(C2=CC=C(N3CCN(CC4=C(CCC(C)(C4)C)C5=CC=C(Cl)C=C5)CC3)C=C2)=O)(=O)=O)=CC=C1N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(C(F)(F)F)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ABT-263
Available
Product Description	Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	974.61
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMF : ≥ 100 mg/mL\|DMSO : 75 mg/mL (ultrasonic)
Target	Bcl-2 Family
Manufacturers Target	Bcl-2 Family
Isoform	Bcl-2; Bcl-W; Bcl-xL
Manufacturers Pathway	Apoptosis
Manufacturers Product type	Reference compound

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HY-10087-10mg-safety-datasheet.pdf