Comparison

GS-444217 European Partner

Item no. HY-100844-10mM
Manufacturer MedChem Express
CASRN 1262041-49-5
Amount 10mM/1mL
Quantity options 100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.67
Formula C23H21N7O
Citations [1]Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128(10):4485-4500.
[2]Budas GR, et al. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197(3):373-385.
Smiles O=C(C1=NC=CC(N2C=C(C3CC3)N=C2)=C1)NC4=CC=CC(C5=NN=CN5C6CC6)=C4
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 1262041-49-5
Available
Product Description
GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM[1].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
Cancer-Kinase/protease
MolecularWeight
411.46
Clinical Information
No Development Reported
Manufacturers Research Area
Cancer
Solubility
DMSO : 15.5 mg/mL (ultrasonic; warming)
Target
Apoptosis; MAP3K
Manufacturers Target
Apoptosis; MAP3K
Isoform
MAP3K5/ASK1
Manufacturers Pathway
Apoptosis; MAPK/ERK Pathway
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10mM/1mL
Available: In stock
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