FCCP

Item no.	HY-100410-100mg
Manufacturer	MedChem Express
CASRN	370-86-5
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Cardiovascular Research Ischemia & Reperfusion Injury Inhibitors & Compound Libraries Small Molecules By Organ Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	99.51
Formula	C10H5F3N4O
Citations	[1]Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.<br/>[2]Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17.<br/>[3]Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.
Smiles	N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Available
Product Description	FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	254.17
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : ≥ 33.3 mg/mL
Target	Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin
Manufacturers Target	Mitochondrial Metabolism; Oxidative Phosphorylation; PINK1/Parkin
Manufacturers Pathway	Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-100410-100mg-safety-datasheet.pdf