SHP099

Item no.	HY-100388-1mg
Manufacturer	MedChem Express
CASRN	1801747-42-1
Amount	1mg
Quantity options	100 mg 10mM/1mL 10 mg 1mg 50 mg 5 mg
Category	Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.80
Citations	ACS Nano. 2023 Aug 14.<br/>Acta Pharm Sin B. 11 August 2021.<br/>Acta Pharm Sin B. 17 February 2022.<br/>Acta Pharm Sin B. 2024 Mar 18.<br/>Ann Transl Med. 2020 Dec;8(23):1570.<br/>Biochem Biophys Res Commun. 2023 Jul 20.<br/>Biochem Biophys Res Commun. 2024 Mar 26, 149812.<br/>bioRxiv. 2019 Sep.<br/>bioRxiv. 2024 Feb 5.<br/>Br J Cancer. 2022 Dec 7.<br/>Brain Pathol. 2020 Mar;30(2):373-385.<br/>Cancer Cell Int. 2021 Jul 3;21(1):337.<br/>Cancer Res Commun. August 17 2022.<br/>Cancer Res. 2021 Apr 5;canres.3738.2020.<br/>Cancers (Basel). 2022 May 12;14(10):2377.<br/>Cell Rep. 2019 Aug 27;28(9):2331-2344.e8.<br/>Cell Syst. 2020 Nov 18;11(5):478-494.e9.<br/>Commun Biol. 2020 Mar 17;3(1):128. <br/>Exp Cell Res. 2022 Sep 21;113361.<br/>Exp Mol Med. 2020 Jun;52(6):911-920.<br/>Exp Ther Med. February 22, 2022.<br/>FEBS Open Bio. 2020 Dec;10(12):2578-2587.<br/>Front Immunol. 21 January 2021.<br/>Hematol Oncol. 2023 Oct 24.<br/>Hepatology. 2018 Jul;68(1):333-348.<br/>Hepatology. 2020 Jul;72(1):155-168. <br/>Inflamm Res. 2023 Jun 23.<br/>J Exp Med. 2022 Apr 4;219(4):e20210739.<br/>J Immunol Res. 2020 Jun 19;2020:4598476.<br/>J Immunol. 2021 Sep 1;207(5):1419-1427.<br/>J Orthop Translat. 2022 Feb 17;32:112-120.<br/>MedComm. 04 March 2022.<br/>Microvasc Res. 2022 Jun 4;104397.<br/>Mol Cell. 2021 Oct 7;81(19):4076-4090.e8.<br/>Mol Med. 2024 Apr 9;30(1):47.<br/>Nat Commun. 2019 Apr 1;10(1):1473. <br/>Nat Commun. 2018 Oct 30;9(1):4507. <br/>Nat Immunol. 2021 Oct 22.<br/>Neural Regen Res. 2024 May 17.<br/>Neural Regen Res. 2025 Mar 1;20(3):858-872.<br/>Neuro Oncol. 2019 Nov 4;21(11):1423-1435. <br/>Patent. US20190231805A1.<br/>Patent. US20220380385A1.<br/>Research Square Preprint. 2021 Apr.<br/>Research Square Preprint. 2021 Mar.<br/>Sci Rep. 2023 Jun 20;13(1):10041.<br/>Signal Transduct Target Ther. 2022 Sep 12;7(1):317.<br/>SSRN. 2020 May.<br/>Theranostics. 2021 Jan 1;11(2):555-566.<br/>Thromb Res. 2023Jun 5.<br/>Acta Pharm Sin B. 11 August 2021.<br/>Cancer Discov. 2018 Oct;8(10):1237-1249. <br/>Cancer Res Commun. 2023 Nov 30.<br/>Cancer Res. 2020 Aug 15;80(16):3413-3423.<br/>Inflammation. 2021 Feb 24.<br/>Open Biol. 2017 May;7(5). pii: 170066.<br/>Patent. US20200330595A1.<br/>[1]Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.<br/>[2]Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52.
Smiles	NC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1801747-42-1
Available
Product Description	SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	352.26
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 12 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic)
Target	Phosphatase; SHP2
Manufacturers Target	Phosphatase; SHP2
Manufacturers Pathway	Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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