A-196

Item no.	HY-100201-100mg
Manufacturer	MedChem Express
CASRN	1982372-88-2
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.73
Formula	C18H16Cl2N4
Citations	[1]Bromberg KD, et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324.
Smiles	ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1982372-88-2
Available
Product Description	A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM, respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	359.25
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 12.5 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Histone Methyltransferase
Manufacturers Target	Histone Methyltransferase
Manufacturers Pathway	Epigenetics
Manufacturers Product type	Reference compound

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HY-100201-100mg-safety-datasheet.pdf