DSM265

Item no.	HY-100184-25mg
Manufacturer	MedChem Express
CASRN	1282041-94-4
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 1mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.76
Formula	C14H12F7N5S
Citations	[1]Kokkonda S, et al. Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparumDihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity. J Med Chem. 2016 Jun 9;59(11):5416-31.<br/>[2]Phillips MA, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med. 2015 Jul 15;7(296):296ra111.
Smiles	CC1=NC2=NC(C(C)(F)F)=NN2C(NC3=CC=C(S(F)(F)(F)(F)F)C=C3)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1282041-94-4
Available
Product Description	DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	415.33
Clinical Information	Phase 2
Manufacturers Research Area	Infection
Solubility	DMSO : 50 mg/mL (ultrasonic)\|Ethanol : 11.11 mg/mL (ultrasonic)
Target	Dihydroorotate Dehydrogenase; Parasite
Manufacturers Target	Dihydroorotate Dehydrogenase; Parasite
Isoform	Plasmodium
Manufacturers Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-100184-25mg-safety-datasheet.pdf