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Vonoprazan

Vonoprazan

Item no.	HY-100007-10mM
Manufacturer	MedChem Express
CASRN	881681-00-1
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 250 mg 50mg
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.89
Formula	C17H16FN3O2S
Citations	Br J Clin Pharmacol. 2019 Jul;85(7):1454-1463.<br/>Toxicol Appl Pharmacol. 2024 Apr 28:486:116945.<br/>Drug Dev Res. 2022 Dec 9.<br/>Drug Metab Dispos. 2016 Oct;44(10):1543-9. <br/>[1]Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456.<br/>[2]Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238.<br/>[3]Sugimoto M, et al. Role of Vonoprazan in Helicobacter pylori Eradication Therapy in Japan. Front Pharmacol. 2019 Jan 15;9:1560.
Smiles	O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TAK-438 (free base)
Available
Product Description	Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+, K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	345.39
Clinical Information	Launched
Manufacturers Research Area	Endocrinology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Bacterial; Proton Pump
Manufacturers Target	Bacterial; Proton Pump
Manufacturers Pathway	Anti-infection; Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-100007-10mM-safety-datasheet.pdf