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Cbl-b-IN-3

Cbl-b-IN-3

Item no.	TMO-T63790-50mg
Manufacturer	TargetMol
CASRN	2573775-59-2
Amount	50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	CN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Short Description	Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.
Shipping	cool pack
Storage	-20°
Molecular Weight	537, 62
Pathway	Ubiquitination
Target	E1/E2/E3 Enzyme

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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Delivery expected until 9/20/2024

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